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What we know about GLP-1 medications in peri/menopausal women GLP-1 and GIP/GLP-1 receptor agonists have been extensively studied and consistently demonstrate substantial weight loss and cardiometabolic benefit in adults with overweight and obesity, including women across the adult lifespan
It's not a minor misstep
One issue to be solved may be the differential expression patterns of SGLT-2 in CNS between human and rodents, although some studies have attempted to describe central distribution and the related function
Hindbrain and septal GLP-1R neurons modulate aversion and satiety
The relatively slow uptake may support stable plasma levels and reduce fluctuations in exposure, which is relevant for compounds intended to act over extended periods
All patients suspected of having an eating disorder should be referred to a specialist for a comprehensive assessment of eating disorder psychopathology before initiating obesity treatment
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